p38 MAPK signalling cascades and inflammatory disease / 医学研究生学报

ABSTRACT

Inflammatory mediators releasing during acute and chronic diseases can activate multiple intracellular signals inducing cascades of the mitogen-activated protein kinase(MAPK) signalling transduction pathway. MAPK plays a significant role in the recruitment of leukocytes to the inflammation sites. Stimulation of leukocytes by pro-inflammatory cytokines is known to activate the MAPK isoform p38. However, the consequences of p38MAPK activation during leukocyte recruitment, adhesion, migration, functions of effector(oxidative burst), and the network of cytokines mediated by p38MAPK are all investigated for further elucidation. Specific p38 inhibitors in reducing the production of inflammatory mediators and providing more effective treatment are now being developed.