High intensity focused ultrasound combined with chemoembolization for malignant tumors: A preliminary study / 中国微创外科杂志

ABSTRACT

Objective To evaluate the short-term efficacy of the combination treatment of high intensity focused ultrasound (HIFU) with transcatheter chemoembolization or systemic intravenous themotherapy in the treatment of malignant solid tumors. Methods Eighty-four patients with malignant tumors were treated by transcatheter chemoembolization or systemic intravenous themotherapy, and then by HIFU, from July 2001 to December 2002. The clinical symptoms, organ functions (ALT、AST), and imaging findings (ECT, MRI or CT) before and after the combination treatment were compared. Results After the combination treatment, the remission rate of clinical symptoms was 92 5% (62/67). Of 56 patients with liver cancer, levels of ALT and AST reduced to normal in 58 9% (33/56) and 66 1% (37/56) of the patients, respectively. An AFP decrease ≥50% of originally numeric value was observed in 71 9% of the patients (23/32). MRI or CT findings indicated that the volume of tumor necrosis was ≥50% in 91 7% of patients (77/84), ≥80% in 61 9% of patients (52/84), and