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Long-term Prognosis of Anti-Neutrophil Cytoplasmic Antibody-Negative Renal Vasculitis: Cohort Study in Korea
Journal of Korean Medical Science ; : 542-546, 2016.
Article in English | WPRIM | ID: wpr-58429
ABSTRACT
Few studies have reported on the long-term prognosis of anti-neutrophil cytoplasmic antibody (ANCA)-negative renal vasculitis. Between April 2003 and December 2013, 48 patients were diagnosed with renal vasculitis. Their ANCA status was tested using indirect immunofluorescence and enzyme-linked immunosorbent assays. During a median (interquartile range) follow-up duration of 933.5 (257.5-2,079.0) days, 41.7% of patients progressed to end stage renal disease (ESRD) and 43.8% died from any cause. Of 48 patients, 6 and 42 were ANCA-negative and positive, respectively. The rate of ESRD within 3 months was higher in ANCA-negative patients than in ANCA-positive patients (P = 0.038). In Kaplan-Meier survival analysis, ANCA-negative patients showed shorter renal survival than did ANCA-positive patients (log-rank P = 0.033). In univariate Cox-proportional hazard regression analysis, ANCA-negative patients showed increased risk of ESRD, with a hazard ratio 3.190 (95% confidence interval, 1.028-9.895, P = 0.045). However, the effect of ANCA status on renal survival was not statistically significant in multivariate analysis. Finally, ANCA status did not significantly affect patient survival. In conclusion, long-term patient and renal survival of ANCA-negative renal vasculitis patients did not differ from those of ANCA-positive renal vasculitis patients. Therefore, different treatment strategy depending on ANCA status might be unnecessary.
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Full text: Available Index: WPRIM (Western Pacific) Main subject: Prognosis / Vasculitis / Severity of Illness Index / Enzyme-Linked Immunosorbent Assay / Proportional Hazards Models / Sex Factors / Retrospective Studies / Risk Factors / Cohort Studies / Follow-Up Studies Type of study: Etiology study / Incidence study / Observational study / Prognostic study / Risk factors Limits: Aged / Female / Humans / Male Country/Region as subject: Asia Language: English Journal: Journal of Korean Medical Science Year: 2016 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Prognosis / Vasculitis / Severity of Illness Index / Enzyme-Linked Immunosorbent Assay / Proportional Hazards Models / Sex Factors / Retrospective Studies / Risk Factors / Cohort Studies / Follow-Up Studies Type of study: Etiology study / Incidence study / Observational study / Prognostic study / Risk factors Limits: Aged / Female / Humans / Male Country/Region as subject: Asia Language: English Journal: Journal of Korean Medical Science Year: 2016 Type: Article