Effect of Xiao Bao Xu on the proliferation of keloid fibroblasts / 中国微创外科杂志

ABSTRACT

Objective To investigate the role of Xiao Ban Xu, a compound Chinese traditional medicinal prescription, on the proliferation of keloid fibroblasts, so as to provide experimental evidence for treating keloid by Chinese traditional medicine. Methods By using hydrocortisone as the experimental control agent, different doses of Xiao Ban Xu were added into cell culture solutions in vitro from 6 samples of keloid fibroblasts (KFB) and 6 samples of normal fibroblasts (NFB). The proliferous activities of KFB and NFB were detected by 3H-TdR method at 12, 24 and 48 hours, respectively. Results The proliferation of NFB and KFB was inhibited by Xiao Ban Xu at 10 ?g/ml, 100 ?g/ml and 1 000 ?g/ml as well as hydrocortisone at 1?10 -7 mol/L at 12, 24 and 48 hours, respectively ( P