Effects of orphanin FQ on endomorphin-1 induced antinociception / 医学研究生学报
Journal of Medical Postgraduates
;
(12)2003.
Article
in Chinese
| WPRIM
| ID: wpr-584337
ABSTRACT
Objective:
To observe the effects of OFQ on endomorphin-1 in pain modulation.Methods:
OFQ and endomorphin-1 were microinjected intracerebroventricularly or intrathecally in rats. The pain thresholds were measured by tail-flick test and acetic-acid induced twitching test, and the changes of antinociceptive effects induced by endomorphin-1 were observed.Results:
OFQ antagonizing endomorphin-1 antinociception at the supraspinal level, while enhancing at the spinal level were observed.Conclusion:
OFQ has functional effects on endomorphin-1 in pain modulation,both in the brain and the spinal cord. The mechanisms of its effect may be different.
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Journal of Medical Postgraduates
Year:
2003
Type:
Article
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