Study of relationship between insulin resistance and activity of PAI-1 in patients with cerebral infarction / 临床神经病学杂志

ABSTRACT

Objective To explore the relationship between insulin resistance (IR) and the activity of plasmingin activator inhibitor-1 (PAI-1) in acute and recovery phases of the patients with arteriosclerotic cerebral infarction (ACI).Methods The levels of fasting serum glucose and free serum insulin were examined, while the activity of tissue-type plasmingin activator (t-PA) and PAI-1 were determined in 91 ACI patients and 40 healthy controls. Insulin sensitivity index (ISI) was estimated by the negative natural logarithm of the verse of fasting serum glucose and insulin product.Results In the acute and recovery phases of the patients with ACI,compared with healthy control group the levels of fasting serum glucose, insulin and activity of PAI-1 were much higher ( P