Two Lung Masses with Different Responses to Pemetrexed
The Korean Journal of Internal Medicine
;
: 213-216, 2010.
Article
in English
| WPRIM
| ID: wpr-58452
ABSTRACT
We described here a patient who had two lung masses. Although the two masses had the same histology and a similar good response to initial chemotherapy with gemcitabine and carboplatin, the response to pemetrexed as a second-line treatment was different after re-growth of the tumors. These two lung masses could have originated from different clones or they could have progressed through different paths of molecular pathogenesis after metastasis, which would lead to different tumor characteristics, including their chemosensitivity. Regardless of their pathogenetic mechanisms, it seems important to recognize that tumors with the same histology that develop in one patient can have different responses to drugs.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Carcinoma, Squamous Cell
/
Carboplatin
/
Neoplasms, Second Primary
/
Drug Resistance, Neoplasm
/
Deoxycytidine
/
Glutamates
/
Guanine
/
Lung Neoplasms
/
Antimetabolites, Antineoplastic
/
Antineoplastic Agents
Limits:
Aged
/
Female
/
Humans
Language:
English
Journal:
The Korean Journal of Internal Medicine
Year:
2010
Type:
Article
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