Changes of Glycogen and Lactate in Cortex of Rats after Exercise-Induced Central System Fatigue / 中国运动医学杂志

ABSTRACT

Objective In order to investigate the changes of glycogen and lactate in cortex after exercise-induced central system fatigue. Methods Central fatigue model was established according to Bedford weight/maximal oxygen uptake equation. The rats were divided into three groups control group (C), sedentary-exhausted group (SE), and overtraining group (O). Results After 1 week exercise, compared with control group, the weight of rats in SE and O group increased slowly. BUN of SE and O group increased significantly to 4.78?1.99 mmol/L and 8.48 ?0.92 mmol/L respectively,but Hb showed no changes. Compared with C group, both DA and DA/5-HT of O group decreased dynamical which were 309.04?63.68 ng/ml?g and 0.42?0.25 respectively. The latency of SEP in O group distinctly delayed, P1 2.98?0.55ms, N1 4.23?0.35ms, P2 5.28?0.60ms. Regarding to 5-HT, no significant difference was found among all groups. Cortex lactate concentration of O (1.46mg/100g )and SE(1.12 mg/100g) group were significantly higher than control group(0.92 mg/100g). There was a tendency of glycogen decrease but had no significant difference among all groups. Conclusion The results suggested that lactate and glycogen might have close relationship with central fatigue and were the possible reasons to cause central fatigue.