Expressions of intercellular adhesion molecule-1, vascular cell adhesion molecule-1 in rat models of cerebral ischemia-reperfusion and the protective effect of ?-Sodium Aescinate / 临床神经病学杂志

ABSTRACT

Objective Study the expressions of intercellular adhesion molecule-1 (ICAM-1), vascular cell adhesion molecule-1 (VCAM-1) in rat models of cerebral ischemia reperfusion and the protective effect of ?-Sodium Aescinate.Methods Rat models of cerebral ischemia-reperfusion were made using an intraluminal monofilament method and ?-Sodium Aescinate was given peritoneally to observe its protective effect. The histochemical change and the expression of ICAM-1, VCAM-1 were detected by HE staining and immunohistochemistry ways.Results (1) ?-Sodium Aescinate could obviously reduce the brain damage after ischemia reperfusion. (2) The expressions of ICAM-1, VCAM-1 in endothelial cells in ischemic territory increased after cerebral ischemia reperfusion. ICAM-1 immunoreactivity peaked at 24 h after reperfusion and VCAM-1 immunoreactivity peaked at 24～48 h after reperfusion. Both of them decreased gradually, but remained a higher level than normal 72 h after reperfusion. (3) ?-Sodium Aescinate could decrease the expressions of ICAM-1, VCAM-1 remarkably 24 h and 48 h after reperfusion.Conclusions High expressions of ICAM-1, VCAM-1 may be involved in the mechanism of cerebral ischemia reperfusion injury. ?-Sodium Aescinate may play its protective role by reducing the expressions of ICAM-1 and VCAM-1.