Protective effects of chitooligosaccharides on CCl_4-induced acute liver injury in mice / 中国海洋药物

ABSTRACT

Objective To investigate the protective effects of chitooligosaccharides on chemical hepatic injury induced by carbon tetrachloride(CCl_4) in mice.Methods Liver injury model was established by administration of CCl_4 in mice.The activities of serum alanine aminotransferase(ALT) and aspartate aminotransferase(AST),the content of malondialdehyde(MDA) and the activity of superoxide dismutase(SOD) in hepatic tissue were measured.The hepatic histological changes were observed by optical microscope. Results Chitooligosaccharides(given at 167,500mg?kg~(-1)?d~(-1)for 7 days) remarkably inhibited the rises of serum ALT and AST,and decreased the content of MDA in hepatic tissues in mice,meanwhile increased the activities of SOD in hepatic tissues.Furthermore,the pathological changes were also significantly improved in the mice of treating group.Conclusion Chitooligosaccharides had protective effects on the acute hepatic injury induced by CCl_4 in mice.