Experimental and Clinical Studies on the Effect of Sodium Dodecylbenzene Sulfonate in in vitro Killing Demodex and in Treating Demodicidosis / 中国寄生虫学与寄生虫病杂志

ABSTRACT

Objective To observe the effect of sodium dodecylbenzene sulfonate (SDBS) in killing Demodex in vitro and in the treatment of demodicidosis. Methods ① The experiment of in vitro killing Demodex with 1% and 2% SDBS was conducted. ② A clinical trial was carried out to evaluate the therapeutic effect in the treatment of demodicidosis with 2% SDBS and 2% metronidazole emulsion. Patients with demodicidosis were randomly divided into trial and control groups (31 cases each). They were treated with 2% SDBS ointment and 2% metronidazole ointment twice a day in the early morning and evening respectively for eight weeks consecutively. Inflammatory lesions of face, Demodex infestation and scores of erythema were measured to evaluate the effect before and after treatment. ③ Follow-up was carried out for two months to evaluate the effect and side-effects after 8 weeks' treatment. Results ① 2% SDBS killed all Demodex in vitro after 5h, there was significant difference between the 2% SDBS and 2% metronidazole (69