New progress of Rapamycin in prevention and treatment of chronic allograft nephropathy / 医学研究生学报

ABSTRACT

Chronic allograft nephropathy(CAN) represents the primary cause of renal graft loss.Calcineurin inhibitor(CI) nephrotoxicity may be one of the most important pathogenetic factors in the development of this CAN.Rapamycin(Rapa)is a new immunosuppressive drug,its mechanism is different from that of CI and without nephrotoxicity.Moreover,Rapa has shown potent antiproliferative activity in different clinical and experimental models.The author reviewed relevant study of Rapa on preventing and treatment CAN.