Screening of the tumor cytotoxic activity of sixteen species of mangrove plants in Hainan / 中国海洋药物

ABSTRACT

Objective To investigate the growth inhibitory effect of the extracts from sixteen species of mangrove plants in Hainan on HeLa cells. Methods Sixteen species of mangrove plants were collected in Wenchang county,Hainan province,and were extracted with ethanol.The ethanol extracts were dissolved in water,partitioned by ethyl acetate,and ethyl acetate and water extract were obtained.Growth inhibitory rates of the extracts on HeLa cells were determined by MTT assay.Results The ethyl acetate extracts from six species of mangrove plants showed growth inhibitory activity on HeLa cells,and the extracts from Acrostichum aureurm and Heritiera littoralis showed strong activity,the IC_(50) values of which were 6.3,9.5 ?g mL~(-1),respectively.Conclusion The ethyl acetate extracts from six species of mangrove plants showed growth inhibitory effects on HeLa cells,whereas the water extracts did not.