Determination and clinical significance of amino acid transmitters in plasma of the patients with ischemic vascular disorders / 中华检验医学杂志

ABSTRACT

Objective To observe the determination and clinical significance of amino acid transmitters in plasmas of the patients with ischemic vascular disorders.Methods Excitatory and inhibitory amino acids in plasmas of 57 old peoples with ischemic vascular disorders and 33 normal old peoples were determined with high performance liquid chromatography(HPLC).Results Significant increases were found in plasma concentration of glutamate(26.48%)、aspartate(39.70%), ?-aminobutyric acid(GABA,74.57%), glycine(36.79%) and alanine(21.33%) within fist three days after cerebral ischemia compared to normal controls. The content of glutamate and aspartate began to increase significantly in 24 hours after ischemia. The plasma levels of glutamate, aspartate and GABA have returned to normal in recovery patients.Conclusions These results showed that the concentration changes of excitatory and inhibitory amino acids in plasmas may suggest the early happening and severity of cerebral ischemia.