Intervention effect of recombinant hirudin on inflammatory reaction in perihematoma of rats with intracerebral hemorrhage / 临床神经病学杂志
Journal of Clinical Neurology
;
(6)1997.
Article
in Chinese
| WPRIM
| ID: wpr-585579
ABSTRACT
Objective To investigate the intervention effect of recombinant hirudin on inflammatory reaction in perihematoma of rats with intracerebral hemorrhage(ICH).Methods ICH models of rats were established by autologous blood injection. Recombinant hirudin was injected into hematoma immediately, 6 h, 12 h after operation, then the expressions of TNF-? and ICAM-1 were detected and myeloperoxidase (MPO) activity was measured in perihematoma.Results TNF-? immune reaction cells, ICAM-1 positive micro-vessels and MPO activity in perihematoma all increased strongly 3 d after ICH ( P
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Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Journal of Clinical Neurology
Year:
1997
Type:
Article
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