Advances in diagnosis and treatment of PADAM / 基础医学与临床

ABSTRACT

The old term of PADAM is "male climacteric" or "andropause" with the synoym of "ADAM" or " late hypogonadism".The serum level of testosterone in male progressives declined after the age of 40 while SHBG increased.At age of 70,around 30% of the total testosterone and 40% of the free testosterone lost.The diagnosis of PADAM is based on the low serum level of androgen and the presence of related symptoms.The basic treatment for PADAM is androgen supplementation(TST).Testosterone undecanoate is a common agent for this purpose.The skin patch or gel of testosterone are also recommended.The benefits of TST are improvement of sexual function,increase of lean body mass,decrease of body fat,enhancement of bone formation and cognition function,and decreased the risks of suffering from type 2 diabetes and cardiovascular disease.On the way of TST,it is necessary to monitor erythrocytes,liver function,prostate digital examination and serum PSA regularly.