Your browser doesn't support javascript.
loading
Changes of synapsin Ⅰ expression and synaptic ultrastructure in hippocampus of the rat models of epilepsy / 临床神经病学杂志
Journal of Clinical Neurology ; (6)1988.
Article in Chinese | WPRIM | ID: wpr-586414
ABSTRACT
Objective To illuminate relationships between epilepsy and functional and morphologic plasticity of synapse through investigating temporal-spatial expression of syanpsinⅠand the alteration of synaptic ultrastructure in hippocampus after seizure. Methods The models of epilepsy were established by injection of pilocarpine and lithium. Electromicroscope and the software of image manipulation were applied to observe the alteration of synaptic ultrastructure in hippocampus during acute phase, resting phase and chronic phase. The expressions of synapsinⅠ were determined by immunohistochemistry. Results The expression of synapsinⅠin every subfield of hippocampus decreased at 3 h after induction of seizure, reached the peak at 6 h and 12 h, which was significantly different from the control ( P

Full text: Available Index: WPRIM (Western Pacific) Language: Chinese Journal: Journal of Clinical Neurology Year: 1988 Type: Article

Similar

MEDLINE

...
LILACS

LIS

Full text: Available Index: WPRIM (Western Pacific) Language: Chinese Journal: Journal of Clinical Neurology Year: 1988 Type: Article