Expression of survivin and cyclin D1 protein in human non-small cell lung carcinoma / 医学研究生学报

ABSTRACT

Objective:To research the expression of survivin and cyclin D1 in human non-small cell lung cancer, and to illustrate their relationship in NSCLC. Methods:Forty-five NSCLC paraffin embe-ded samples were collected. Survivin and cyclin D1 were tested by immunohistochemical S-P method. Results:No survivin expression was present in normal lung tissues. The positive rate of survivin in NSCLC was 60% (27/45). By statistic analysis, the significant differences were found in different pathological grading and clinical phased lymph node involvement. The patient' s gender, age and histological classification were not related with the expression of survivin. Conclusion:Survivin may play an im-portment role in the process of carcinogenesis and development of NCLC. Survivin and cyclin D1 might play synergetic roles in lung cancer cell' s karyokinesismitosis and they can be identified as potential therapeutic target in NSCLC.