The Expressions of PDGF-C, PDGF-D and PDGF Receptors in Renal Development Model / 대한신장학회잡지
Korean Journal of Nephrology
;
: 170-180, 2005.
Article
in Korean
| WPRIM
| ID: wpr-58660
ABSTRACT
BACKGROUND:
Four platelet derived growth factor (PDGF) family members have been identified; the classical PDGFs, PDGF-A and PDGF-B, and the novel PDGFs, PDGF-C and PDGF-D, which were only recently discovered.METHODS:
The present study was designed to determine the changes of the platelet derived growth factor (PDGF) subtypes (C & D) and their receptors (PDGFR)-alpha & beta expression in kidneys during pre- and postnatal development.RESULTS:
All the protein levels of PDGFR-alpha and -beta and the mRNA levels of PDGF-C and D were high in kidneys during the prenatal period and decreased differently during the postnatal period. PDGFR-alpha was expressed in the interstitial space at embryo day 18. PDGFR-beta protein were expressed in metanephric blastema at embryo day 18. PDGF-C mRNA was expressed in metanephric blastema, developing glomerulus at embryo 18 day and in collecting duct at postnatal day 7. PDGF-D mRNA was expressed in the parietal and vesceral epithelial cells during pre and postnatal period.CONCLUSION:
These results indicate that the PDGF subtypes (C & D) and their receptors (PDGFR-alpha & -beta) are differently expressed in the kidney during the prenatal and postnatal period.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Platelet-Derived Growth Factor
/
RNA, Messenger
/
Receptors, Platelet-Derived Growth Factor
/
Embryonic Structures
/
Epithelial Cells
/
Rabeprazole
/
Kidney
Type of study:
Prognostic study
Limits:
Humans
Language:
Korean
Journal:
Korean Journal of Nephrology
Year:
2005
Type:
Article
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