Liver asialoglycoprotein receptor scintigraphy:a new prospect of segmentational three-dimensional evaluation of liver function / 基础医学与临床

ABSTRACT

Asialoglycoprotein receptor(ASGPR) is a specific receptor of mammalian hepatocytes.Reduction in ASGPR concentration has been proven to appear in liver cirrhosis and liver cancer.By liver ASGPR scintigraphy with 99mTcGSA,some indexes such as HH15、LHL15、[R]_0、R_0 can be obtained,which is useful for the evaluation of liver function.When combining with the techniques of functional scintigraphy and single photon emission computed tomography(SPECT),it becomes possible to functionally simulate the extension of hepatic resection and predict to some extent postoperative outcomes related to liver function.It is still a new professional field internationally,and almost absent domestically.It could be an important tool for quantificational evaluation of the risk of liver surgery and help determining the surgical procedures.We have here,with some of our research experiences in this field,written a review of ASGPR scintigraphy.