The associations of single nucleotide polymorphisms on bactericidal/permeability-increasing protein and lipopolysaccharide-binding protein with the susceptibility of infection / 医学研究生学报
Journal of Medical Postgraduates
;
(12)2003.
Article
in Chinese
| WPRIM
| ID: wpr-586775
ABSTRACT
Objective:
To investigate the associations of single nucleotide polymorphisms(SNP) on bactericidal/permeability-increasing protein(BPI) and lipopolysaccharide-binding protein(LBP) with the complication of sepsis.Methods:
The SNP genotypes of BPI Lys216Glu,PstⅠin intron 5,G545C,LBP Cys98Gly and Leu436Pro were examined by restriction fragment length polymorphism PCR(PCR-RFLP).Results:
The rate of BPI Lys216Glu G/G genotypes and G-alleles in patients with sepsis were significantly higher than that of volunteers.The rate of BPI Lys216Glu G/G genotypes and G-alleles in nonsurviving patients were significantly higher than that of survivor patients.Conclusion:
The BPI Lys216Glu G-allele may be associated with the high risk of sepsis.
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Journal of Medical Postgraduates
Year:
2003
Type:
Article
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