Association between genetic polymorphisms of exon3 of nicotinic acetylcholine receptor ?4 subunit and sporadic Alzheimer's disease / 临床神经病学杂志
Journal of Clinical Neurology
;
(6)1993.
Article
in Chinese
| WPRIM
| ID: wpr-586801
ABSTRACT
Objective To investigate the association between genetic polymorphisms of exon3 of nicotinic acetylcholine receptor ?4 subunit (CHRNA4) and sporadic Alzheimer's disease(SAD).Methods In 23 SAD patients and 30 people of normal control, exon3 of CHRNA4 was screened by PCR-DGGE and DNA sequencing.Results Three new genetic polymorphisms were found in the exon3 of CHRNA4 C104T, A136G, G169A.The frequnces of these three genes in SAD group were 35%,46%,61% respectively and in control group were 13%,13%,33% respectively. There were significant difference between two groups (all P
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Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Journal of Clinical Neurology
Year:
1993
Type:
Article
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