The efficacy and safety of tirofiban during perioperation of emergency percutanous coronary intervention in acute myocardial infarction / 中国介入心脏病学杂志

ABSTRACT

Objective To observe the efficacy and safety of applying platelet glycoprotein Ⅱb/Ⅲa receptor antagonist(tirofiban) during the perioperation period of emergency percutaneous coronary intervention(PCI) in acute myocardial infarction(AMI).Methods Patients with coronary artery TIMI blood flow 0-1 grade and underwent emergency PCI were consecutively randomized into tirofiban group(n=45) and control group(n=45).Tirofiban was used in the former group before operation and continued for 36-48 hours after PCI.In the latter group,PCI was performed through routine process.The reflow rate,30 days reinfarction rate,mortality and platelet activation degree before and after PCI were recorded during the study.Results All patients in the tirofiban group were recovered with TIMI 3 grade flow and neither slow-reflow nor no-reflow phenomena were observed.In the control group 88.90% of patients restored TIMI 3 grade flow and 11.10% of patients were just recovered with TIMI 0-2 grade flow.The difference was found to be statistically significant(P