Effects of taurine on streptozotocin-induced apoptosis and expression of BCL-xL and BAX in rat pancreatic islet cells / 基础医学与临床
Basic & Clinical Medicine
;
(12)2006.
Article
in Chinese
| WPRIM
| ID: wpr-586859
ABSTRACT
Objective To investigate the inhibition effect of taurine on the apoptosis of isolated pancreatic islet cells insulin secretion,the expression of BCL-xL and BAX induced by streptozotocin.Methods Isolated pancreatic islet cells from Wistar rats of 3 to 5 days were incubated in monolayer in vitro.(NO_2~-/NO_3~-) production,NOS activity,insulin secretion,expression of BCL-xL and BAX,apoptotic rate of islet cells after and DNA fragmentation in pancreatic islet cells after incubation with streptozotocin were measured,and the potential effects of taurine was investigated.Results Streptozotocin induced a significant increase in apoptotic rate of pancreatic islet cells(from(4.0?0.7)% to(40.5?5.7)%),DNA ladder appearance,a decrease of insulin content,up-regulation of the expression of BAX and down-regulation of the expression of BCL-xL(P
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Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Basic & Clinical Medicine
Year:
2006
Type:
Article
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