Development of platelet rich plasma in bone tissue engineering / 医学研究生学报

ABSTRACT

Platelet rich plasma is an autologous concentration of platelet that has a 4 to 5-fold or more increase over baseline platelet number,and it is a concentration of the growth factors proved to be actively secreted by platelets to initiate all wound healing.PRP enhances bone marrow stromal cells and osteoblasts proliferation in vitro.PRP combined with ?-tricalcium phosphate,bioceramic or autogenous bone enhance the bone healing considerably.PRP is effective in accelerating bone regeneration for the treatment of periodontal defect after surgical extraction of an impacted mandibular third molar.PRP combined with autogenous bone,bovine-derived xenograft or hydroxyapatite improve the osteogenesis of alveolar bone grafting in alveolar clefts or periodontal intrabony defect patients.Culture-expanded bone marrow stromal cells and autologous PRP injected into the distracted callus can shorten the treatment period by acceleration of bone regeneration during distraction osteogenesis.PRP works via the degranulation of the ? granules in platelets,which contain the synthesized and prepackaged growth factors.Little benefit from PRP may be due to use of damaged platelets or non-critical-sized bone defect models.The value of PRP is its proven effectiveness,its safety,its cost effectiveness,and its availability in an easy-to-develop manner.