The expression level of hypoxi-inducible factor-1? in bone marrow biopsies of acute leukemia and the relationship with angiogenesis / 医学研究生学报

ABSTRACT

Objective: To explore the expression level of hypoxi-inducible factor-1? and the relationship with angiogenesis in bone marrow biopsies of acute leukemias. Methods: Bone marrow biopsies from 10 controls and 20 acute leukemias were embedded in glycol-methacrylate(GMA) resin.EnVison two-step immunohistochemical staining method was used to show the expression level of HIF-1? and microvessel density.Results: The low expression level of HIF-1? protein in acute leukemias was observed in 1 case,middle level in 5 cases,high level in 6 cases and very high level in 8 cases,while in controls,high level in 3 cases and middle level in 7 cases.There was statistical significance between two groups(P