Intervention effect of local application of recombinant hirudin on neuronal apoptosis in intracerebral hemorrhage of rats / 临床神经病学杂志
Journal of Clinical Neurology
;
(6)1995.
Article
in Chinese
| WPRIM
| ID: wpr-587202
ABSTRACT
Objective To investigate the intervention effect of recombinant hirudin on apoptosis of neurons in intracerebral hemorrhage (ICH) of rats.Methods ICH animal models were established by autologous blood injection, and hirudin, a special inhibitor of thrombin, was used for intervention treatment. The neurologic impairment scores (NIS) of rats were measured, and TUNEL-positive cells and caspase-3 IR cells were also detected in cortex and basal ganglia 24 h after operation.Results After intervention treatment of recombined hirudin, the NIS of rats decreased obviously ( P
Full text:
Available
Index:
WPRIM (Western Pacific)
Type of study:
Prognostic study
Language:
Chinese
Journal:
Journal of Clinical Neurology
Year:
1995
Type:
Article
Similar
MEDLINE
...
LILACS
LIS