Differential diagnostic value of Parkinson's disease and essential tremor by ~ ( 99m)Tc-TRODAT-1 SPECT imaging of dopamine transporter / 临床神经病学杂志

ABSTRACT

Objective To investigate the value of brain ~ 99mTc-TRODAT-1 SPECT in differentiation of essential tremor (ET) from Parkinson's disease (PD) at early stage. Methods SPECT imaging with ~ 99mTc-TRODAT-1 was conducted in 28 patients with PD at early stage, 15 patients with ET, 8 patients with ET combined with PD and 15 healthy subjects. The interesting regions including bilateral striatum (ST) and occipital lobe (OC) were figured, and the radioactivity counts of these three regions were obtained by computer automatically. The ratio of specific radioactivity uptake and asymmetry indexes of the four groups were calculated and compared.Results The ratio of specific radioactivity uptake was 0.58?0.16 (left side) and 0.56?0.32 (right side) in healthy group, 0.55?0.22 (left side) and 0.56?0.24 (right side) in ET group. There was no significant difference between the two groups. The ratio of specific radioactivity uptake was 0.44?0.33 (left side) and 0.45?0.18 (right side) in ET-PD group, 0.40?0.33 (side contralateral to onset or more severe limbs) and 0.51?0.12 (ipsilateral side) in PD group. The ratios of specific radioactivity uptake in PD and ET-PD groups were significantly lower than those in ET and healthy groups ( P