D-test for Detection of Inducible Resistance to Clindamycin in Staphylococci / 中华医院感染学杂志

ABSTRACT

OBJECTIVE To apply D-test for detection of inducible resistance of erythromycin to clindamycin in staphylococci and investigate their resistant rate to erythromycin and clindamycin. METHODS According to the standards of NCCLS to detect inducible resistance of erythromycin to clindamycin in staphylococci . RESULTS Co-resistance to erythromycin and clindamycin accounted for 50% and 22.8% in 77 strains of staphylococci (20 of S.aureus and 57 of coagulase-negative staphylococci). The rate of erythromycin resistance and clindamycin sensitivity accounted for 20% and 59.6%. D-test positive rate was 50% and 61.8% of which were erythromycin resistant and clindamycin sensitive respectively. CONCLUSIONS D-test for detection of inducible resistance of erythromycin to clindamycin in staphylococci should be checked in clinical microbiology laboratory in order to help physicians to select MLSb antimicrobial agents correctly.