Antimalarial Activity of C-10 Substituted Triazolyl Artemisinin
The Korean Journal of Parasitology
;
: 661-665, 2017.
Article
in English
| WPRIM
| ID: wpr-58758
ABSTRACT
We synthesized C-10 substituted triazolyl artemisinins by the Huisgen cycloaddition reaction between dihydroartemisinins (2) and variously substituted 1, 2, 3-triazoles (8a-8h). The antimalarial activities of 32 novel artemisinin derivatives were screened against a chloroquine-resistant parasite. Among them, triazolyl artemisinins with electron-withdrawing groups showed stronger antimalarial activities than those shown by the derivatives having electron-donating groups. In particularly, m-chlorotriazolyl artemisinin (9d-12d) showed antimalarial activity equivalent to that of artemisinin and could be a strong drug candidate.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Parasites
/
Artemisinins
/
Cycloaddition Reaction
Language:
English
Journal:
The Korean Journal of Parasitology
Year:
2017
Type:
Article
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