Effect of amylin on biomechanical properties of the femur in glucocorticoid-induced osteoporosis rats / 医学研究生学报
Journal of Medical Postgraduates
;
(12)2003.
Article
in Chinese
| WPRIM
| ID: wpr-587594
ABSTRACT
Objective:
To investigate the effect of amylin on biomechanical property of the femur in glucocorticoid-induced osteoporosis rats.Methods:
Four groups of female Wistar rats(3 months old) were treated for 12 weeks as follows ⅠNormal Control;ⅡDXM;Ⅲ DXM+AMY;Ⅳ DXM+Vitamin D_3.By intramuscular injection of dexamethasone(DXM)1mg/kg twice a week during the first 8 weeks,the animal model of Glucocorticoid induced osteoporosis was established.After 12 weeks,biomechanical properties of the femur were measured.Results:
After the treatment with AMY,Bone structural mechanical(diameter) and geometrical parameters(displacement,peak load) of the femur were significantly increased(vs.DXM group,P
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Journal of Medical Postgraduates
Year:
2003
Type:
Article
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