Changes in plasma pro-brain natriuretic peptide concentration before and after interventional therapy in congenital heart diseases / 中国介入心脏病学杂志

ABSTRACT

Objective To investigate the relationship between plasma pro-brain natriuretic peptide (N-pro-BNP) level and heart function, as its well as change before and after interventional therapy. Methods Fifty-eight children with left to right shunt congenital heart diseases were enrolled from July, 2004 to Jan, 2005. Clinical heart function were categorized and plasma N-pro-BNP concentration were detected. The ejection fraction (EF), fractional shortening (FS) and left ventricular and diastolic dimension (LVDd) were measured by two-dimensional echocardiography. The relationship between plasma pro-BNP concentration and the echo parameters, and its change before and after interventional therapy were analyzed. Results The plasma N-pro-BNP concentration, LVDd, EF and FS before and after intervention were 194.7?154.7 ng/L vs 561.0?594.2 ng/L (P