Studies on the tumor cytotoxic constituents from the marine sponge Hyrtios erectus / 中国海洋药物

ABSTRACT

Objective To investigate the cytotoxic constituents from the sponge Hyrtios erectus.Methods The constituents were isolated and purified by column chromatography,and their structures were identified by physicochemical data,spectral data,and comparison with data of references.The cytotoxic activity of all the compounds was determined by MTT mothod.Results Five compounds were isolated from the lipid extract of Hyrtios erectus,and their structures were elucidated as Hyrtiosal(Ⅰ),12?-Hydroxy-16-scalaren-24,25-olide(Ⅱ),5-Hydroxy-1H-indole-3-ethanol(Ⅲ),cholesterol(Ⅳ),and dibutylphthalate(Ⅴ) respectively.Conclusion Compound were isolated from Hyrtios erectus for the first time, and compound Ⅰand Ⅱ showed strong cytotoxic activity.