NS-398 inhibites MVD value and VEGF、MMP-9 expression of hepatocullar carcinoma SMMC-7721 cells and xenograft tissue / 基础医学与临床
Basic & Clinical Medicine
;
(12)2006.
Article
in Chinese
| WPRIM
| ID: wpr-587677
ABSTRACT
Objective To explore the role of NS-398 on MVD and VEGF、MMP-9 expression of hepatocullar carcinoma.Methods VEGF and MMP-9 expressions were detected by RT-PCR and flow cytometry.Microvascular density of xenograft tissue were detected by immunohistochemical staining and the serum PGE_(2) was detected by ELISA.Results The expression of VEGF and MMP-9 was significantly downregulated in SMMC-7721 cells exposed to(NS-398) in a dose-dependence and time-dependent manner(P
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Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Basic & Clinical Medicine
Year:
2006
Type:
Article
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