Effect of Pancreatic Kininogenase on Ventriculer Remodeling in Spontaneously Hypertensive Rats / 中华高血压杂志
Chinese Journal of Hypertension
;
(12)2006.
Article
in Chinese
| WPRIM
| ID: wpr-587836
ABSTRACT
Objective To investigate the effect of pancreatic kininogenase on the expression of matrix metalloproteinases-2 2(MMP-2), transfer growth factor-?_ 1 (TGF-?_ 1 ) and ventriculer remodeling in spontaneously hypertensive rats (SHR). Methods Twenty-four male 15 weeks SHR were randomly divided into three groups SHR group, pancreatic kininogenase treatment group(PK 7.2 U/kg?d), captopril treatment group(Cap 10 mg/kg?d)(n=8 in each), 8 Wister Kyoto were served as control. After four weeks, blood pressure were measured througth carotid artery catherization. Myocardial tissue was stained with VG and pathological changes were studied. MMP-2, TGF-?_ 1 were determined by immunohisto-chemical technique(SP method). Results In pancreatic kininogenase treated SHR, SBP(183?12 vs SHR 234?23)mm Hg, LVMI(2.89?0.15 vs SHR 3.06?0.18)mg/g, CVF(0.17?0.03 vs SHR 0.26?0.05)%, PVCA(0.57?0.26 vs SHR 0.99?0.47)% and expression of MMP-2, TGF-?_ 1 in SHR were significantly improved (P
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Chinese Journal of Hypertension
Year:
2006
Type:
Article
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