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Effect of Stress on Hippocampal Monoamine Metabolism in Rat under Simulated High-altitude Hypobaric Hypoxia / 中国心理卫生杂志
Chinese Mental Health Journal ; (12)2002.
Article in Chinese | WPRIM | ID: wpr-587896
ABSTRACT

Objective:

To examine the effect of psychological and physiological stress on monoamine in extracellular fluid of hippocampus under simulated high-altitude hypobaric hypoxia.

Methods:

Psychological and physiological stress were made by the way of communication box.The hypoxia disposal was that the rats were put hypobaric chamber at a simulated altitude of 6000 meters for 24 hours.We compared the effect of stress in different sorts and intensity on the contents of norepinephrine(NE),dopamine(DA),5-hydroxytryptamine(5-HT)in extracellular fluid of hippocampus.The extracellular fluid of hippocampus of rat was collected by push-pull perfusion;we determined the contents of monoamine in it by high performance liquid chromatography with electrichemical detection(HPLC-ECD).

Results:

(1)The simulated high-altitude hypobaric hypoxia reduced the content of NE in extracellular fluid of hippocampus(813.8?196.1/1209.2?282.0,P

Full text: Available Index: WPRIM (Western Pacific) Language: Chinese Journal: Chinese Mental Health Journal Year: 2002 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Language: Chinese Journal: Chinese Mental Health Journal Year: 2002 Type: Article