Multimarker Approach in Discriminating Patients with Symptomatic and Asymptomatic Atherosclerotic Carotid Artery Stenosis
Journal of Clinical Neurology
;
: 165-175, 2013.
Article
in English
| WPRIM
| ID: wpr-58791
ABSTRACT
BACKGROUND AND PURPOSE:
Several circulating biomarkers have been implicated in carotid atherosclerotic plaque rupture and thrombosis; however, their clinical utility remains unknown. The aim of this study was to determine the role of a large biomarker panel in the discrimination of symptomatic (S) vs. asymptomatic (A/S) subjects in a contemporary population with carotid artery stenosis (CS).METHODS:
Prospective sampling of circulating cytokines and blood lipids was performed in 300 unselected, consecutive patients with > or =50% CS, as assessed by duplex ultrasound (age 47-83 years; 110 with A/S and 190 with S) who were referred for potential CS revascularization.RESULTS:
CS severity and pharmacotherapy did not differ between the A/S and S patients. The median values of total cholesterol, low-density lipoprotein cholesterol, and lipoprotein(a) did not differ, but high-density lipoprotein (HDL) cholesterol was significantly higher (p1.37 (third quartile). In S-CS, osteoprotegerin and lipoprotein-associated phospholipase A2 (Lp-PLA2) were elevated in those with recent vs. remote symptoms (p=0.01 and p=0.02, respectively).CONCLUSIONS:
In an all-comer CS population on contemporary pharmacotherapy, low HDL-cholesterol (but not other previously implicated or several novel circulating biomarkers) is an independent predictor of S-CS status. In addition, an increase in circulating osteoprotegerin and Lp-PLA2 may transiently indicate S transformation of the carotid atherosclerotic plaque.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Rupture
/
Triglycerides
/
C-Reactive Protein
/
Fibrinogen
/
Biomarkers
/
Carotid Arteries
/
Logistic Models
/
Odds Ratio
/
Cholesterol
/
Prospective Studies
Type of study:
Diagnostic study
/
Etiology study
/
Observational study
/
Prognostic study
/
Risk factors
Limits:
Humans
Language:
English
Journal:
Journal of Clinical Neurology
Year:
2013
Type:
Article
Similar
MEDLINE
...
LILACS
LIS