The relationship of Met326Ile variant of p85? regulatory subunit of phosphatidylinositol 3-kinase(PI3-K) with type 2 diabetes / 中国糖尿病杂志

ABSTRACT

0.05),and the distribution of genotypes was in Hardy-Weinberg equilibrium.Data analysis showed Met326Ile variant did not impact on FIns,FPG,HOMA index,BMI and gene expression of PI3-K,though the expression of PI3-K gene was lower in type 2 diabetes than in control group.Conclusion The Met326Ile variant of the p85? regulatory subunit of PI3-K is likely to be functionally normal in type 2 diabetes and health people.