Impact of cervical intraepithelial neoplasia and its treatments on pregnancy / 基础医学与临床

ABSTRACT

Cervical intraepithelial neoplasia is a preinvasive lesion of cervical carcinoma associated with HPV infection.It can be classified as low or high grade according to the degree of the lesion.Low grade lesion includes HPV infection and CIN1,and high grade lesion includes CIN2～3.HPV infection and CIN have become very common among fertile women,so more and more attention has been paid to the influence that HPV infection,cervical lesion and their treatments would have on pregnancy.HPV infection may increase during pregnancy period.Tough there will be more chances for the vaginal delivery infants to be exposed to HPV,it is not proper to draw a conclusion that cesarean must be performed for all HPV infected pregant women.If CIN1 is found during pregnancy,observation and close follow-up post partum should be advised.Pregnancy may not deteriorate CIN2～3,but clear diagnosis should be made during pregnancy if colposcopy examination result is not satisfactory or great doubt for invasive cancer exits.In this case,conization during the second semester of the pregancy is advised,which may increase the cesarean rate.Conservative therapy for CIN has not significant influnce on fertility,while cold knife conization and LEEP conization may increase the premature delivery rate,which may be associated with premature ruption of fetal membrane.