HPV infection and preinvasive disease of cervix / 基础医学与临床

ABSTRACT

Cervical carcinoma is a continuous pathological procedure from preinvasive lesion to carcinoma.Cervicalintraepithelial neoplasia-the preinvasive disease of cervix carcinoma-is currently regarded to be associated with HPV infection.HPV is a small double-stranded DNA virus composed of protein shell and DNA core.The gene group includes early coding region,late coding region and long control region.E6 and E7 protein which are coded in the early coding region play a crucial role in virus copy.HPVs in reproductive system are very common in sex-active people.At least 75% of women who have sexual life will infect HPVs in some period of their life.Most of them can regress,and only those infected by high risk type virus and combined with other high risk factors could progress to HSIL or cervical carcinoma.As to HPV infection,people should neither overlook it nor got scared.Currently,treatment of the local vulva or cervical lesion caused by HPV infection is the most effective.