The Effect of Silk Fibroin-Alginic Acid Sponge Treatment as an Artificial Skin on Wound
Journal of the Korean Society of Plastic and Reconstructive Surgeons
;
: 413-422, 2006.
Article
in Korean
| WPRIM
| ID: wpr-58816
ABSTRACT
PURPOSE:
This study was designed to compare the wound healing effect of silk fibroin, alginate and fibroin/ alginate blend sponge with clinically used Nu gauze in a rat skin defect model.METHODS:
Two full thickness excisions were made on the back of Sprague-Dawley rat. The excised wound was covered with either of the silk fibroin(SF), alginate (SA), or fibroin/alginate blend sponge(SF/SA). On the postoperative days of 3, 7, 10 and 14, the wound area was calculated by image analysis software. At the same time, a skin wound tissue was biopsied.RESULTS:
Healing time 50% (HT(50)) of SF/SA sponge treated group was dramatically reduced as compared with that of control treatment. We also found that the HT50 of SF/SA sponge was significantly decreased as compared with either those of SF or SA treatment. Furthermore, SF/SA treatment significantly increased the size of epithelialization and collagen deposition as well as the number of PCNA positive cells on epidermal basement membrane as comapred with those of control treatment.CONCLUSION:
Our results suggest that the wound healing effect of SF/SA blend sponge is the best among other treatments including SF and SA during the whole wound healing period.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Porifera
/
Skin
/
Basement Membrane
/
Wound Healing
/
Wounds and Injuries
/
Collagen
/
Rats, Sprague-Dawley
/
Skin, Artificial
/
Proliferating Cell Nuclear Antigen
/
Silk
Limits:
Animals
Language:
Korean
Journal:
Journal of the Korean Society of Plastic and Reconstructive Surgeons
Year:
2006
Type:
Article
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