The Role of TNF-alpha in Eosinophilic Inflammation of RSV Bronchiolitis / 소아알레르기및호흡기학회지
Pediatric Allergy and Respiratory Disease
;
: 46-53, 2008.
Article
in Korean
| WPRIM
| ID: wpr-58832
ABSTRACT
PURPOSE:
Tumor necrosis factor (TNF)-alpha and eosinophilic inflammation have their role in asthma, but there were no studies on respiratory syncytial virus (RSV) bronchiolitis. The aim of our study was to investigate whether TNF-alpha has a role in eosinophilic inflammation of lower respiratory tract infections with RSV and has the correlation with other cytokines.METHODS:
Fifty children with first RSV bronchiolitis (RSV group) and 18 healthy children without any respiratory symptom and sign (control group) were enrolled. Clinical data, such as eosinophil-derived neurotoxin (EDN), eosinophil cationic protein (ECP), were analyzed. We measured interleukin (IL)-5, IL-8, TNF-alpha, granulocyte macrophage-colony stimulating factor (GM-CSF), interferon (IFN)-gamma, eotaxin, and regulated on activation, normal T cell expressed and secreted (RANTES) in nasal lavage fluid in both groups.RESULTS:
Eotaxin, GM-CSF, IL-8, IFN-gamma and TNF-alpha were higher in the RSV group than the control group. TNF-alpha correlated with an eosinophil-active cytokine, GM-CSF (r=0.86, P<0.0001), IFN-gamma (r=0.90, P<0.0001), and with eosinophil-active C-C chemokines such as eotaxin (r=0.50, P<0.0001). TNF-alpha also correlated with proinflammatory cytokines such as IL-8 (r= 0.81, P<0.0001).CONCLUSION:
TNF-alpha correlated with eosinophil-active chemokines and cytokines. Therefore, TNF-alpha may have a role in eosinophilic inflammation in children with RSV bronchiolitis.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Respiratory Syncytial Viruses
/
Respiratory Tract Infections
/
Asthma
/
Bronchiolitis
/
Cytokines
/
Granulocyte-Macrophage Colony-Stimulating Factor
/
Interleukin-8
/
Interleukins
/
Interferons
/
Tumor Necrosis Factor-alpha
Limits:
Child
/
Humans
Language:
Korean
Journal:
Pediatric Allergy and Respiratory Disease
Year:
2008
Type:
Article
Similar
MEDLINE
...
LILACS
LIS