Drug-resistance of Commonly Encountered Pathogens from Nosocomial Infection / 中华医院感染学杂志

ABSTRACT

OBJECTIVE To investigate the distribution of pathogens from nosocomial infection,and provide reference for the clinical rational use of drugs.METHODS Flora authentication and bacteriostatic test were operated routinely and with microorganism automatic identifier,and supplement bacteriostatic test was operated with Kirby-Bauer method if necessary.Results were judged according to the standard of NCCLS.RESULTS Totally 5 487 pathogens were mainly from phlegm,urine,blood and secretion;the most commonly encountered pathogens were Escherichia coli,Pseudomonas aeruginosa, Acinetobacter,Staphylococcus aureus and S.epidermidis.The rates were 25.1%,18.6%,8.9%,8.4% and 2.9%,respectively;the rates of drug-resistance to sulperazon and imipenem were all below 22.1%.The positive rates of ESBLs from E.coli,Klebsiella pneumoniae and Enterobacter cloacae were from 17.3% to 30.3%;Gram-positive cocci′s amikacin-resistant rate and vancomycin-resistant rate were below 7.2% and 2.2%,respectively.CONCLUSIONS E.coli,P.aeruginosa,Acinetobacter,S.epidermidis and Candida albicans are the main pathogens from nosocomial infection;vancomycin is the first choice to treat meticillin-resistant Staphylococcus;sulperazon and imipenem are the first choice to treat zymogenic bacteria and non-fermentative bacilli infection.