Antibiotic Resistance of Extended-spectrum ?-Lactamases in Escherichia coli and Klebsiella pneumoniae / 中华医院感染学杂志

ABSTRACT

OBJECTIVE To investigate the incidence of extended-spectrum ?-lactamases(ESBLs) of Escherichia coli and Klebsiella pneumoniae and to observe their relationship with antibiotic resistance patterns during the last one and a half years in our hospital.METHODS The API half-automicroscan system was used to identify the pathogenic bacteria and conduct drug resistance test.RESULTS The incidence of ESBLs was 22.2% in E.coli and 21.8% in K.pneumoniae.ESBLs producing strains were more resistant to penicillins and cephalosporins,but few of which were resistant to imipenem and meropenem.The resistance rate of ESBLs producing strains to antibacterial agents was higher than of non-ESBLs producing strains.CONCLUSIONS Extended-spectrum ?-lactamases play a most important role in bacterial resistance to penicillins and cephalosporins.Detecting ESBLs strains producing rate and their susceptibility to antibiotics is very important in guiding the clinical administration of drugs.