Semi-quantitative Procalcitonin Assay in Critically ill Patients with Respiratory infections / 결핵및호흡기질환
Tuberculosis and Respiratory Diseases
;
: 205-211, 2009.
Article
in Korean
| WPRIM
| ID: wpr-58893
ABSTRACT
BACKGROUND:
Serum procalcitonin level has been considered prognostic during sepsis and septic shock. We investigated the significance of procalcitonin in critically ill patients with respiratory infections.METHODS:
The patients who had radiographically diagnosed diffuse lung infiltrations were enrolled on a prospective basis. Bronchoalveolar lavage (BAL) fluid for the purpose of quantitative cultures (> or =10(4) cfu/mL) was obtained from all patients. Serum procalcitonin levels determined by PCT-Q kit were measured on BAL day and classified as follows; 10.0 ng/mL. We analyzed the patient's characteristics according to outcome; favorable or unfavorable, defined as death.RESULTS:
Patients from the following categories were included medical 17 (47.2%), surgical 9 (25%), and burned 10 (27.8%). APACHE II scores on admission to intensive care unit were 11.5+/-6.89 and 11 (30.6%) had unfavorable outcomes. A procalcitonin level > or =0.5 ng/mL was in 17 (47.2%) of all. On univariate analysis, the frequencies of burn injury, mechanical ventilation, multiple organ failure, and a procalcitonin level > or =0.5 ng/mL were more often increased in patients with unfavorable outcomes than in those with favorable outcomes (p or =0.5 ng/mL was more sensitive in predicting VAP than unfavorable outcome.CONCLUSION:
A higher procalcitonin level seems to be associated with VAP, but further study is required to know that procalcitonin would be a prognostic marker in critically ill patients with respiratory infections.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Protein Precursors
/
Respiration, Artificial
/
Respiratory Tract Infections
/
Shock, Septic
/
Burns
/
Calcitonin
/
Multivariate Analysis
/
Prospective Studies
/
Critical Illness
/
Sepsis
Type of study:
Observational study
/
Prognostic study
Limits:
Humans
Language:
Korean
Journal:
Tuberculosis and Respiratory Diseases
Year:
2009
Type:
Article
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