Angiotensin converting enzyme gene polymorphism in children with Henoch-Schonlein purpura nephritis / 医学研究生学报
Journal of Medical Postgraduates
;
(12)2003.
Article
in Chinese
| WPRIM
| ID: wpr-589117
ABSTRACT
Objective:
To invesgate the correlation between Angiotensin converting enzyme(ACE) gene polymorphism and Henoch-Schonlein purpura nephritis(HSPN) in children.Methods:
According to the clinical features,pathological changes,48 HSPN children have been devided into 4 clinical types,Uab,I-GH,R-GH and NS type,and Ⅱ-Ⅳ 3 histological degrees respectively.The correlations between serum ACE level,ACE gene polymorphism and clinical presentation,pathlogical changs,effect to therapy were analyzed.Results:
In the 48 patients,35(72.9%),4(8.3%),4(8.3%) and 5(10.5%) patients belonged to Uab type,I-GH type,R-GH type and NS type respectively.20(41.7%),19((39.6%)) and 9(18.7%) patients belonged to Ⅱ,Ⅲ and Ⅳ histological degrees respectively.5 patients had DD genotype,25 patients had ID genotype and 18 patients had II genotype.The mean serum ACE level of DD genotype patients was(39.60?11.40)U/L,which was significant higher than that of ID genotype patients[(24.29?11.62)(U/L) and II genotype patients(4.49?11.41)U/L](P
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Journal of Medical Postgraduates
Year:
2003
Type:
Article
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