Soluble dispersive mixture of chicken collagen type Ⅱ delays the morphological changes of articular cartilage in rats with osteoarthritis: Comparison among different oral doses and excipients / 中国组织工程研究

ABSTRACT

0.05). ②Therapeutic study The Mankin's score of OA group was higher than high or low SmCCⅡ group (6.96?1.02), (3.08?0.45), (4.00?0.94) respectively, P 0.05). CONCLUSION: SmCCⅡ can delay the degradation of articular cartilage of OA rats and maybe effective for OA prevention or treatment. The mechanism maybe related to SmCCⅡ reducing the synthesis of MMP-13, MMP-9 and Cath K at transcriptional level.