Study on coagulant state in deep vein thrombosis patients with low level of coagulant factor Ⅻ / 临床检验杂志

ABSTRACT

Ojective To study the coagulant state in the patients with deep vein thrombosis(DVT)caused by low level of coagulant factor Ⅻ.Methods Blood samples were obtained from 125 patients with deep veins thrombosis and 32 normal people(control group).Before thrombolysis the following parameters were testedthrombolysis ⅫC coagulant activity(FⅫC),prothrombin time(PT),activated prothrombin time(APTT),thrombin time(TT),fibrinogen(FIB),antithrombin activity(ATA),D-dimer(D-D),plasminogen activity(PLGA),lupus anticoagulant(LAC),protein C(PC),tissue plasminogen activator antigen(t-PAAg),plasminogen activator inhibitor-1 antigen(PAIAg).According to the activity of FⅫC,the patients were divided into 2 groupsnormal ⅫC group and low FⅫC group.Results The PLGA,PC,ATA,t-PAAg in the low FⅫC group was lower evidently than those in normal group(P0.05).Compared to the FⅫC normal group,t-PAAg in the low FⅫC group decreased(P