Estrogen deprivation and excess energy supply accelerate 7,12-dimethylbenz(a)anthracene-induced mammary tumor growth in C3H/HeN mice
Nutrition Research and Practice
;
: 628-636, 2015.
Article
in English
| WPRIM
| ID: wpr-58995
ABSTRACT
BACKGROUND/OBJECTIVES:
Obesity is a risk factor of breast cancer in postmenopausal women. Estrogen deprivation has been suggested to cause alteration of lipid metabolism thereby creating a cellular microenvironment favoring tumor growth. The aim of this study is to investigate the effects of estrogen depletion in combination with excess energy supply on breast tumor development. MATERIALS/METHODS:
Ovariectomized (OVX) or sham-operated C3H/HeN mice at 4 wks were provided with either a normal diet or a high-fat diet (HD) for 16 weeks. Breast tumors were induced by administration of 7,12-dimethylbenz(a)anthracene once a week for six consecutive weeks.RESULTS:
Study results showed higher serum concentrations of free fatty acids and insulin in the OVX+HD group compared to other groups. The average tumor volume was significantly larger in OVX+HD animals than in other groups. Expressions of mammary tumor insulin receptor and mammalian target of rapamycin proteins as well as the ratio of pAKT/AKT were significantly increased, while pAMPK/AMPK was decreased in OVX+HD animals compared to the sham-operated groups. Higher relative expression of liver fatty acid synthase mRNA was observed in OVX+HD mice compared with other groups.CONCLUSIONS:
These results suggest that excess energy supply affects the accelerated mammary tumor growth in estrogen deprived mice.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Breast Neoplasms
/
RNA, Messenger
/
Receptor, Insulin
/
Risk Factors
/
Postmenopause
/
Tumor Burden
/
Diet
/
Estrogens
/
Lipid Metabolism
/
Fatty Acids, Nonesterified
Type of study:
Etiology study
/
Risk factors
Limits:
Animals
/
Female
/
Humans
Language:
English
Journal:
Nutrition Research and Practice
Year:
2015
Type:
Article
Similar
MEDLINE
...
LILACS
LIS