Association between immunological and inflammatory reactions and type 2 diabetic macrovascular / 中国医师杂志

ABSTRACT

ObjectiveTo investigate the effect of immunological and inflammatory reactions on type 2 diabetic macrovascular disease.Methods120 patients with type 2 diabetes mellitus and 60 health controls were enrolled in this study.The patients were divided into two sub - groups,type 2 diabetes mellitus group and type 2 diabetic macrovascular disease group.The markers of immunological and inflammatory reactions were detected,and the main associated factors were collected and analyzed by one -way ANOVA and logistic regression.ResultsThe level of FBG,PPG,HbA1c,Hs-CRP and TNF-αt [ (9.86 ± 1.79)mmol/L,( 14.45 ±5.48) mmol/L,( 11.43 ±3.25) ％,(6.79 ±3.71 )mg/L,( 1.99 ±0.65) ng/ml] in the group of type 2 diabetic macrovascular disease group were higher than type 2 diabetes mellitus group [ (7,25±0.64)mmol/L,(10.45 t2.89) mmol/L,(8.56 ±1.58)％,(4.72 ±2.39) ag/L,(1.24 ±0.44) ng/ml,P ＜ 0.05 ].The risk factors in type 2 diabetic macrovascular disease were TNF-α,Hs-CRP and HbA1 c.ConclusionsImmunological and inflammatory reactions play a key role in type 2 diabetic macrovascular disease.